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KMID : 0061119830110000153
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Bulletin of the Clinical Research Institute
1983 Volume.11 No. 0 p.153 ~ p.153
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Uitrastructural Changes on the Renal corpuscles after Removal of Ureteral Obstruction in Raabbits
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Kim Tae-Kyung
Lim Su-Kil
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Abstract
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This study was designed to clarify morphological changes in the renal corpuscles of the rabbit kidneys after unilateral ureteral obstruction and subsequent release of ureteral obstruction through light and electron microscopy.
It was further aimed at obtaining data, esp. of an electron microscopy, concerning the morphological recovery after relieving ureteral obstruction.
A total of 25 white rabbits weighing about 2.5 kg were used. These were divided into three groups; normal control, unilateral ureteral obstruction and release after unilateral obstruction.
The normal ´control group consisted of 5 rabbits.
The left ureter of the remaining 20 rabbits were completely ligated with silk ligature.
Ten obstructed kidneys were studied by light and electron microscopy, five of them two weeks after obstruction and the other five four weeks after obstruction.
Ten postobstructed ureters were relieved by ureteroneocystostomy as described by MacKinnon et al. (1968) in 2nd week and 4th week after ureteral occlusion. There kidneys were studied for light and electron microscopy 15 days after relieving ureteral obstruction.
The results of this study were as follows:
1. Deformity of Bowman´s capsular epithelium such as irregular basal invaginations facing with the basal lamina was observed in the two week obstructed kidneys, and severe degenerative changes such as desquamated capsular epithelial cells in the Bowman´s space and long basal cytoplasmic processes embedded in the basal lamina in the four week obstructed kidneys.
2. Among the postobstructed kidneys, ` morphological changes in the two week obstructed kidneys were restored to near normal on the 15th` day, but, in the four week obstructed kidneys, Bowman´s capsular epithelium revealed partial recovery.
3. The results indicate that glomeruli in the renal corpuscle were preserved until four weeks after ureteral obstruction but Bowman´s capsular epithelium showed abnormal changes even in the 2nd weeks and severe degenerative changes of Bowman´s capsular epithelium were noticed in the 4th week after ureteral obstruction.
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